研究論文

【英文原著論文】

【2023年】

Rikiya Imamura,  Mizuki Saito,  Mikio Shimada,  Junya Kobayashi,  Masamichi Ishiai, Yoshihisa Matsumoto

APTX acts in DNA double-strand break repair in a manner distinct from XRCC4

Journal of Radiation Research, rrad007, https://doi.org/10.1093/jrr/rrad007

Published:  20 March 2023 Section:  Regular Paper

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Shimada M, Tokumiya T, Miyake T, Tsukada K, Kanzaki N, Yanagihara H, Kobayashi J, Matsumoto Y.J

Implication of E3 ligase RAD18 in UV-induced mutagenesis in human induced pluripotent stem cells and neuronal progenitor cells

J Radiat Res. 2023 Jan 11:rrac099. doi: 10.1093/jrr/rrac099. Online ahead of print.

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【2022年】

Kakeya H, Matsumoto Y. A probabilistic approach to evaluate the likelihood of artificial genetic modification and its application to SARS-CoV-2 Omicron variant. IPSJ Transactions on Bioinformatics, 15, 22-9 (2022).

（リンク：https://www.jstage.jst.go.jp/article/ipsjtbio/15/0/15_22/_article/-char/ja/）

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Mikio Shimada and Tomoko Miyake

DNA damage signaling, cell reprogramming, and differentiation

Epigenetics and DNA Damage, Volume 33 in Translational Epigenetics

2022, Pages 157-166

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Tsuchiya H, Shimada M, Tsukada K, Meng Q, Kobayashi J, Matsumoto Y.

THE ROLE OF DNA DOUBLE-STRAND BREAK REPAIR THROUGH NON-HOMOLOGOUS END JOINING IN THE DOSE-RATE EFFECT IN TERMS OF CLONOGENIC ABILITY.

Radiat Prot Dosimetry. 2022 Sep 9;198(13-15):990-997. doi: 10.1093/rpd/ncac030.

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Yoshihisa Matsumoto.

Development and Evolution of DNA-Dependent Protein Kinase Inhibitors toward Cancer Therapy.

Int J Mol Sci. 2022 Apr 12;23(8):4264. doi: 10.3390/ijms23084264.

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【2021年】

Tomoko Miyake, Munekazu Kuge, Yoshihisa Matsumoto, Mikio Shimada (corresponding author)

α-glucosyl-rutin activates immediate early genes in human induced pluripotent stem cells.

Stem Cell Research, published online 20 Aug. https://doi.org/10.1016/j.scr.2021.102511

Matsumoto Y (corresponding author), Asa ADDC, Modak C, Shimada M.

DNA-dependent protein kinase catalytic subunit: The sensor for DNA double -strand breaks structurally and functionally related to ataxia telangiectasia mutated.

Genes (Basel). 2021 Jul 27;12(8):1143. doi: 10.3390/genes12081143.

Someya M, Tsuchiya T, Fukushima Y, Hasegawa T, Hori M, Kitagawa M, Gocho T, Mafune S, Ikeuchi Y, Hirohashi Y, Torigoe T, Iwasaki M, Matsuura M, Saito T, Matsumoto Y, Sakata K. 

Prediction of treatment response from the microenvironment of tumor immunity in cervical cancer patients treated with chemoradiotherapy. 

Medical Molecular Morphology, published online 8 May 2021. DOI: 10.1007/s00795-021-00290-w.

Matsumoto H, Shimada Y, Nakamura AJ, Usami N, Ojima M, Kakinuma S, Shimada M, Sunaoshi M, Hirayama R, Tauchi H.

Health effect triggered by tritium: how do we get public understanding based on scientifically supported evidence?

Journal of Radiation Research. 2021 Apr 28:rrab029. doi: 10.1093/jrr/rrab029.

Anie Day D.C. Asa, Rujira Wanotayan, Mukesh Kumar Sharma, Kaima Tsukada, Mikio Shimada, Yoshihisa Matsumoto (corresponding author).

Functional Analysis of XRCC4 Mutations in Reported Microcephaly and Growth Defect Patients in Termsof Radiosensitivity.

Journal of Radiation Research, 2021 Apr 12

Tomoko Miyake and Mikio Shimada (corresponding author)

3D organoid culture using skin keratinocytes derived from human induced pluripotent stem cells. 

Methods in Molecular Biology, 2021 Mar 11

【2020年】

*Matsumoto Y, Sharma MK. 

DNA‑Dependent Protein Kinase in DNA Damage Response: Three Decades and Beyond. 

J. Rad. Cancer Res. 11, 123-34, 2020

Hasegawa T, Someya M, Hori M, Tsuchiya T, FukushimaY, Matsumoto Y, Sakata K. 

Predicting the results of radiotherapy for prostate cancer with an artificial neural network and assessment of Ku70 expression. 

In Vivo, 34(5), 2865-2872 (2020).

Tsuchiya H, Shimada M, Tsukada K, Meng Q, Kobayashi J, Matsumoto Y (corresponding author).

Diminished or inversed dose-rate effect on clonogenic ability in Ku-deficient rodent cells.

Journal of Radiation Research, 2020 Dec 29:rraa128. doi: 10.1093/jrr/rraa128.

Tsukada K, Shimada M (corresponding author), Imamura R, Saikawa K, Ishiai M, Matsumoto Y.

The FHA domain of PNKP is essential for its recruitment to DNA damage sites and maintenance of genome stability.

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Available online 2 November 2020

Tsukada K, Matsumoto Y, Shimada M (corresponding author).

Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase.

PLoS One. 2020 Sep 24;15(9):e0239404. doi: 10.1371/journal.pone.0239404. eCollection 2020

Okawa A, Morioka T, Imaoka T, Kakinuma S, Matsumoto Y (Corresponding author). 

Differential expression of DNA-dependent protein kinase catalytic subunit in the brain of neonatal mice and young adult mice. 

Proc. J. Acad. Ser. B., 96(5), 171-179 (2020). DOI: 10.2183/pjab.96.014.

Shimada M (Corresponding author), Miyake T.

In Reply to Nguyen et al.

Int J Radiat Oncol Biol Phys. 2020 Mar 1;106(3):650. doi: 10.1016/j.ijrobp.2019.11.403.

【2019年】

Shimada M (corresponding author), Tsukada K, Kagawa N, Matsumoto Y.

Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells.

Journal of Radiation Research, 2019 Nov

Miyake T, Shimada M (corresponding author), Matsumoto Y, Okino A.

DNA damage response after ionizing radiation exposure in skin keratinocytes derived frome human induced pluripotent stem cells.

Int J Radiat Oncol Biol Phys. 2019 May 11

Kitagawa M, Someya M, Hasegawa T, Mikami T, Asaishi K, Hasegawa T, Matsumoto Y, Kutomi G, Takemasa I, *Sakata K.

Influence of XRCC4 expression by breast cancer cells on ipsilateral recurrence after breast-conserving therapy.

Strahlentherapie und Oncologie, published online (2019).

Nishikubo K, Izumi Y, Matsumoto Y, Fujii K, Matsuo K, *Yokoya A. 

Structural analysis of DNA repair protein XRCC4 applying circular dichroism in an aqueous solution. 

Radiat. Protect. Dosim., 183(1-2), 36-39 (2019).

【2018年】

Amiri Moghani AR, Sharma MK, *Matsumoto Y.

In cellulo phosphorylation of DNA double-strand break repair protein XRCC4 on Ser260 by DNA-PK. 

J. Radiat. Res., 59(6), 700-708, (2018).

Sunatani Y, Kamdar RP, Sharma MK, Matsui T, Sakasai R, Hashimoto M, Ishigaki Y, Matsumoto Y, *Iwabuchi K. 

Caspase-mediated cleavage of X-ray repair cross-complementing group 4 promotes apoptosis by enhancing nuclear translocation of caspase-activated DNase. 

Exp. Cell Res., 362, 450-460 (2018).

【2017年】

Shimada Mikio (corresponding author), Tsuchiya Hisayo, Matsumoto Yoshihisa

Effect of different dose rates of ionizing radiation on ciliogenesis in hTRET-RPE1 cells

Special Issue of For the Fifth International Symposium on Innovative Nuclear Energy Systems   131 444-447  

*Someya M, Hasegawa T, Hori M, Matsumoto Y, Nakata K, Masumori N, Sakata K. 

Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy.

J. Radiat. Res., 58, 225-231 (2017).　 doi: 10.1093/jrr/rrw099.

Hasegawa T, Someya M, Hori M, Matsumoto Y, Nakata K, Nojima M, Kitagawa M, Tsuchiya T, Masumori N, Hasegawa T, *Sakata K. Expression of Ku70 predicts results of radiotherapy in prostate cancer. 

Strahlenther. Onkol., 193, 29-37 (2017). DOI 10.1007/s00066-016-1023-7

【2016年】

Hori M, Someya M, Matsumoto Y, Nakata K, Kitagawa M, Hasegawa T, Tsuchiya T, Fukushima Y, Gocho T, Sato Y, Ohnuma H, Kato J, Sugita S, Hasegawa T, *Sakata K. 

Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy. 

Med. Mol. Morphor., in press (2016).

Takada Y, Someya M, Matsumoto Y, Satoh M, Nakata K, Hori M, Saito M, Horikawa N, Tateoka K, Teramoto M, Saito T, Hasegawa T, *Sakata K. 

Influence of Ku86 and XRCC4 expression in uterine cervical cancer on the response to preoperative radiotherapy. 

Med. Mol. Morphor., Doi 10.1007/s-00795-016-0136-5 (2016).

Jun S, Jung Y-S, Suh HN, Wang W, Kim MJ, Oh YS, Lien E, Shen X, Matsumoto Y, McCrea P, Li L, Chen J, *Park J-I. 

LIG4 mediates Wnt signaling-induced radioresistance. 

Nat. Commun., 7, 10994 (2016). doi: 10.1038/ncomms10994

Shimada M, Matsuzaki F, Kato A, Kobayashi J, Matsumoto T, Komatsu K. 

Induction of Excess Centrosomes in Neural Progenitor Cells during the Development of Radiation-Induced Microcephaly. 

PLoS One. 2016 Jul 1;11(7)

【2015年】

Sharma MK, Imamichi S, Fukuchi M, Samartha RM, Tomita M, *Matsumoto Y. 

In cellulo phosphorylation of XRCC4 Ser320 by DNA-PK induced by DNA damage. 

J. Radiat. Res., 57, 115-120 (2016). doi: 10.1093/jrr/rrv086 (2015)

Björkman A, Du L, Felgentreff K, Rosner C, Kamdar RP, Kokaraki G, Matsumoto Y, Davies EG, van der Burg M, Notarangelo LD, Hammarström L, *Pan-Hammarström Q. 

DNA-PKcs is involved in immunoglobulin class switch recombination in human B-cells. 

J. Immunol., 195, 5608-5615 (2015). doi:10.4049/jimmunol.1501633

Fukuchi M, Wanotayan R, Liu S, Imamichi S, Sharma MK, Matsumoto Y*. 

Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV. 

Biochem. Biophys. Res. Commun., 461, 687-694 (2015).

Wanotayan R, Fukuchi M, Imamichi S, Sharma MK, Matsumoto Y*. 

Asparagine 326 in the extremely C-terminal region of XRCC4 is essential for the cell survival after irradiation. 

Biochem. Biophys. Res. Commun., 457, 526-531 (2015). doi:10.1016/j.bbrc.2015.01.015. PMID: 25597996

Shimada M, Dumitrache LC, Russell HR, McKinnon PJ. 

Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. 

EMBO J. 2015 Oct 1;34(19):2465-80.

【2014年】

3.Imamichi S, Sharma MK, Kamdar RP, Fukuchi M, Matsumoto Y*.

Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK. 

Proceedings of Japan Academy Series B, 90, 365-372 (2014). PMID: 23994631

Katyal S, Lee Y, Nitiss KC, Downing SM, Li Y, Shimada M, Zhao J, Russell HR, Petrini JH, Nitiss JL, McKinnon PJ.

Aberrant topoisomerase-1 DNA leisons are pathogenic in neurodegenerative genome instability syndromes.

Nat Neurosci. 2014 Jun;17(6):813-21.

【2013年】

4.Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y*.

C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin. 

Biochem. Biophys. Res. Commun., 439, 173-178 (2013). 

Shimada M, Hirayama R, Komatsu K.

High LET radiation amplifies centrosome overduplication through a pathway of γ-tubulin monoubiquitination.

Int J Radiat Oncol Biol Phys. 2013 Jun 1;86(2):358-65.

【2012年】

Urushihara Y, Kobayashi J, Matsumoto Y, Komatsu K, Oda S, Mitani H*. 

DNA-PK inhibition causes a low level of H2AX phosphorylation and homologous recombination repair in Medaka (Oryzias latipes) cells. 

Biochem. Biophys. Res. Commun., 429, 131-136 (2012). DOI: 10.1016/j.bbrc.2012.10.128. PMID: 23142596

Ito Y, Ito T, Karasawa S, Enomoto T, Nashimoto A, Hase Y, Sakamoto S, Ito T, Mimori T, Matsumoto Y, Yamaguchi Y, Handa H*. Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A. 

PLoS ONE, 7(12), e50481 (2012). DOI: 10.1371/journal.pone.0050481. PMID: 23227178

Someya M, Sakata K*, Matsumoto Y, Tauchi H, Kai M, Hareyama M, Fukushima, M. 

Effects of depletion of dihidropyrimidine dehydrogenase on focus formation and RPA phosphorylation. 

J. Radiat. Res., 53, 250-256 (2012). PMID: 22510597

Miura K, Sakata K*, Someya M, Matsumoto Y, Matsumoto H, Takahashi A, Hareyama M. 

The combination of olaparib and camptothecin for effective radiosensitization. 

Radiat. Oncol., 96, 259-266 (2012). DOI: 10.1186/1748-717X-7-62. PMID: 22524618

Takagi M, Sakata K*, Someya M, Matsumoto Y, Tauchi H, Hareyama M. and Fukushima, M. 

The combination of hyperthermia or chemotherapy with gimeracil for effective radiosensitization. 

Strahlenther. Onkol., 188, 256-261 (2012). DOI: 10.1007/s00066-011-0043-6. PMID: 22322869

Hayashi J, Sakata K*, Someya M, Matsumoto Y, Satoh M, Kataya K, Hori M, Takagi M, Hareyama M.

Analysis of Ku and XRCC4 expressions of hypopharyngeal cancer tissues and results treated with chemoradiotherapy. 

Oncol. Lett., 4, 151-155 (2012). DOI: 10.3892/ol.2012.674. PMID: 22807979

【2011年】

Sakata K*, Someya M, Matsumoto Y, Tauchi H, Kai M, Toyota M, Takagi M, Hareyama M, Fukushima M. 

Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. 

Cancer Sci., 102, 1712-1716 (2011) DOI: 10.1111/j.1349-7006.2011.02004.x. PMID: 21668582

Tsuchimoto,T., Sakata,K.*, Someya,M., Yamamoto,H., Hirayama,R., Matsumoto,Y., Furusawa,Y. and Hareyama,M. 

Gene expression associated with DNA-dependent protein kinase activity under normoxia, hypoxia and reoxygenation. 

J.Radiat.Res., 52, 464-471 (2011) DOI: 10.1269/jrr.10137. PMID: 21905307

Someya,M., Sakata,K.*, Matsumoto,Y., Kamdar,R.P., Kai,M., Toyota,M. and Hareyama,M. 

The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer. 

Brit. J. Cancer, 104, 1724-1729 (2011) DOI: 10.1038/bjc.2011.158. PMID: 21559021

Shimada M, Kato A, Habu T, Komatsu K.

Genistein, isoflavonoids in soybeans, prevents the formation of excess radiation-induced centrosomes via p21 up-regulation.

Mutat Res. 2011 Nov 1;716(1-2):27-32.

Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira DV, Shimada M, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K.

Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.

Mol Cell. 2011 Mar 4;41(5):515-28.

Shimada M, Kato A, Kobayashi J.

Potential role of DNA repair factor in centrosome maintenance.

DNA repair 4, Intech Publisher, 2011.

【2010年】

14.Takagi,M., Sakata,K.*, Someya,M., Tauchi,H., Iijima,K., Matsumoto,Y., Torigoe,T., Takahashi,A., Hareyama,M. and Fukushima,M. Gimeracil sensitizes cells to radiation via inhibition of homologous recombination. 

Radiother. Oncol., 96, 259-266 (2010) DOI: 10.1016/j.radonc.2010.05.020. PMID: 20584556

15.Kamdar,R.P. and Matsumoto,Y.* 

Radiation-induced XRCC4 Association with Chromatin DNA Analyzed by Biochemical Fractionation. 

J.Radiat.Res., 51, 303-313 (2010). PMID: 20448413

16.Sasano,N., Enomoto,A., Hosoi,Y., Katsumura,Y., Matsumoto,Y., Morita,A., Shiraishi,K., Miyagawa,K., Igaki,H. and Nakagawa,K.* Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations. 

Cancer Lett., 293, 521-527 (2010). doi: 10.1016/j.canlet.2009.12.020. PMID: 20092938

17.Morita,A.*, Yamamoto,S., Wang,B., Tanaka,K., Suzuki,N., Aoki,S., Ito,A., Nanao,T., Ohya,S., Yoshino,M., Zhu,J., Enomoto,A., Matsumoto,Y., Funatsu,O., Hosoi,Y. and Ikekita,M.* 

Sodium orthovanadate inhibits p53-mediated apoptosis. 

Cancer Res., 70, 257-265 (2010). DOI: 10.1158/0008-5472.CAN-08-3771. PMID: 2004807

Shimada M, Kobayashi J, Hirayama R, Komatsu K.

Differential role of repair proteins, BRCA1/NBS1 and Ku70/DNA-PKcs, in radiation-induced centrosome overduplication.

Cancer Sci. 2010 Dec;101(12):2531-7.

【2009年】

Shimada M, Komatsu K.

Emerging connection between centrosome and DNA repair machinery.

J Radiat Res. 2009 Jul;50(4):295-301. 

Shimada M, Sagae R, Kobayashi J, Habu T, Komatsu K.

Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.

Cancer Res. 2009 Mar 1;69(5):1768-75.

【2008年】

18.Iwabuchi,K.*, Matsui,T., Hashimoto,M., Matsumoto,Y., Kurihara,T. and Date,T. 

Characterization of a cancer cell-line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1. 

Biochem.Biophys.Res.Commun., 379, 509-513 (2008). DOI: 10.1016/j.bbrc.2008.09.022. PMID: 18804090

19.Tomita,M.*, Morohoshi,F., Matsumoto,Y., Ohtsuka,K., Nomura,T. and Sakai,K. 

Roles of DNA double-strand break repair genes in sustaining cell proliferation under low dose-rate irradiation. 

J. Radiat. Res., 49, 557-564 (2008). PMID: 18797158

20.Enomoto, A.*, Kido, N., Ito, M., Morita, A., Matsumoto, Y., Takamatsu, N., Hosoi, Y. and Miyagawa, K. 

Negative regulation of MEKK1/2 signaling by Serine-Threonine kinase 38 (STK38). 

Oncogene, 27, 1930-1938 (2008). PMID: 17906693

【2007年】

21.Someya, M., Sakata, K.*, Matsumoto, Y., Satoh, M., Narimatsu, H. and Hareyama, M. 

Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues. 

Oncology Reports, 18, 1483-1487 (2007). PMID: 17982634

22.Sasano, N., Enomoto, A., Hosoi, Y., Katsumura, Y., Matsumoto, Y., Shiraishi, K., Miyagawa, K., Igaki, H. and Nakagawa, K.* 

Free radical scavenger edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells. 

J. Radiat. Res., 48, 495-504 (2007). PMID: 17965547

23.Someya, M., Sakata, K.*, Matsumoto, Y., Tauchi, H., Narimatsu, H. and Hareyama, M. 

Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients. 

Oncology Reports, 18, 873-878 (2007). PMID: 17786349

24.Sakata, K.*, Yamamoto, H., Matsumoto, Y., Someya, M. and Hareyama, M. 

cDNA analysis of gene expression associated with DNA-dependent protein kinase activity.

Int. J. Oncol., 30, 413-420 (2007). PMID: 17203223

【2006年】

25.Hosoi, Y.*, Kapp, L. N., Murnane, J. P., Matsumoto, Y., Enomoto, A., Ono, T. and Miyagawa, K. 

Suppression of anchorage-independent growth by expression of ataxia-telangiectasia group D complementing gene, ATDC. 

Biochem. Biophys. Res. Commun., 348, 728-734 (2006). PMID: 16890201

26.Someya, M., Sakata, K.*, Tauchi, H., Matsumoto, Y., Nakamura, A., Komatsu, K. and Hareyama, M. 

Association of ionizing radiation-induced foci of NBS1 with chromosomal instability and breast cancer susceptibility. 

Radiat. Res., 166, 575-582(2006). PMID: 17007554

27.Someya, M., Sakata, K.* Matsumoto, Y., Yamamoto, H., Monobe, M., Ikeda, H., Ando, K., Hosoi, Y., Suzuki, N. and Hareyama, M. 

The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer. 

Carcinogenesis, 27, 117-122 (2006). PMID: 16000400

28.Li, Z., Hosoi, Y.*, Cai, K., Tanno, Y., Matsumoto, Y., Enomoto, A. Morita, A. Nakagawa, K. and Miyagawa, K. 

Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation. Biochem. Biophys. Res. Commun., 342, 363-368 (2006). PMID: 16414009

29.Tonotsuka, N., Hosoi, Y.*, Miyazaki, S., Miyata, G., Sugawara, K., Mori, T., Ouchi, N., Satomi, S., Matsumoto, Y., Nakagawa, K., Miyagawa, K. and Ono, T. 

Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.

Int. J. Mol. Med., 18, 441-447 (2006). PMID: 16865228

【2005年】

30.Yuita, H., Tsuiji, M., Tajika, Y., Matsumoto, Y., Hirano, K., Suzuki, N. and Irimura, T.* 

Retardation of removal of radiation-induced apoptotic cells in developing neural tubes in macrophage galactose-type C-type lectin-1-deficient mouse embryos. 

Glycobiology, 15, 1368-1375 (2005). PMID: 16096344

31.Komuro, Y.*, Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Suzuki, N. and Nagawa, H. 

Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer. Hepato-Gastroenterology, 52, 995-998 (2005). PMID: 16001615

32.Morita, A.*, Zhu, J., Suzuki, N., Enomoto, A., Matsumoto, Y., Tomita, M., Suzuki, T., Ohtomo, K. and Hosoi, Y. Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. 

Cell Death Diff. 13, 499-511 (2005). PMID: 16138109

【2004年】

33.Komiyama, S., Taniguchi, S., Matsumoto, Y.*, Tsunoda, E., Ohto, T., Suzuki, Y., Yin, H.-L., Tomita, M., Enomoto, A., Morita, A., Suzuki, T., Ohtomo, K., Hosoi, Y. and Suzuki N. 

Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53. 

Biochem. Biophys. Res. Commun., 323, 816-822 (2004). PMID: 15381073

34.Yin, H.-L., Suzuki, Y., Matsumoto, Y.*, Tomita, M., Furusawa, Y., Enomoto, A., Morita, A., Aoki, M., Yatagai, F., Suzuki, T., Hosoi, Y., Ohtomo, K. and Suzuki, N. 

Radiosensitization by hyperthermia in chicken B lymphocyte cell line DT40 and its derivatives lacking non-homologous end-joining and/or homologous recombination pathways of DNA double-strand break repair. 

Radiat. Res., 162, 433-441 (2004). PMID: 15447039

35.Hosoi, Y.*, Matsumoto, Y., Enomoto, A., Morita, A., Green, J., Nakagawa, K., Naruse, K. and Suzuki, N. 

Suramin Sensitizes Cells to Ionizing Radiation by Inactivating DNA-Dependent Protein Kinase. 

Radiat. Res. 162, 308-314 (2004). PMID: 15378840

36.Hosoi, Y.*, Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A., Nagawa, H. and Suzuki, N. 

Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. 

Int. J. Oncol. 25, 461-468 (2004). PMID: 15254745

【2003年】

37.Umeda, N., Matsumoto, Y.*, Yin, H.-L., Tomita, M., Enomoto, A., Morita, A., Mizukoshi, T., Sakai, K., Hosoi, Y. and Suzuki, N. Difference in the heat sensitivity of DNA-dependent protein kinase activity among mouse, hamster and human cells. Int. J. Radiat. Biol., 79, 671-680 (2003). PMID: 14555350

38.Enomoto, A., Suzuki, N.*, Kang, Y., Hirano, K., Matsumoto, Y., Zhu, J., Morita, A., Hosoi, Y., Sakai, K. and Koyama, H. Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukemia cell line MOLT-4. Int. J. Radiat. Biol., 79, 589-600 (2003). PMID: 14555342

39.Komuro, Y.*, Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Saito, S., Ishihara, S., Kazama, S., Tsuno, N., Kitayama, J., Suzuki, N., Tsurita, G., Muto, T. and Nagawa, H. Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression. J. Exp. Clin. Cancer Res., 22, 223-228 (2003). PMID: 12866572

40.Tomita, M., Suzuki, N.*, Matsumoto, Y., Enomoto, A., Yin, H.-L., Hosoi, Y., Hirano, K. and Sakai, K. Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway. Radiat. Res., 160, 467-477 (2003). PMID: 12968928

41.Enomoto, A.*, Suzuki, N., Morita, A., Ito, M., Liu, C. Q., Matsumoto, Y., Yoshioka, K., Shiba, T. and Hosoi, Y. Caspase-mediated cleavage of JNK during stress-induced apoptosis. Biochem. Biophys. Res. Commun., 306, 837-842 (2003). PMID: 12821118

【2002年】

42.Hosoi, Y.*, Matsumoto, Y., Tomita, M., Enomoto, A., Morita, A., Sakai, K. Umeda, N., Zhao, H.-J., Nakagawa, K., Ono, T. and Suzuki, N. Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity. Brit. J. Cancer, 86, 1143-1149 (2002). PMID: 11953863

43.Komuro, Y.*, Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Tsuno, N., Kazama, S., Kitayama, J., Suzuki, N. and Nagawa, H. The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma. Cancer 95, 1195-1205 (2002). PMID: 12216085

44.Yoshida, M., Hosoi, Y.*, Miyachi, H., Ishii, N., Matsumoto, Y., Enomoto, A., Nakagawa, K., Yamada, S., Suzuki, N. and Ono, T. Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells. Int. J. Radiat. Biol. 78, 503-512 (2002). PMID: 12065055

【2001年】

45.Mori, N.*, Matsumoto, Y., Okumoto, M.,Suzuki, N. and Yamate, J. Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis. Oncogene, 20, 3609-3619 (2001). PMID: 11439324

46.Sakata, K.*, Matsumoto, Y., Satoh, M., Oouchi, A., Nagakura, H., Koito, K., Hosoi, Y., Hareyama, M., and Suzuki, N. Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas. Radiat. Med., 19, 93-97 (2001). PMID: 11383649

47.Sakata, K.*, Matsumoto, Y., Tauchi, H., Satoh, M., Oouchi, A., Nagakura, H., Koito, K., Hosoi, Y., Suzuki, N., Komatsu, K., and Hareyama, M. Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues. Int. J. Radiat. Oncol. Biol. Phys., 49, 161-167 (2001). PMID: 11163510

48.Enomoto, A., Suzuki, N.*, Liu, C., Kang, Y., Zhu, J., Serizawa, S., Matsumoto, Y., Morita, A., Ito, M., and Hosoi, Y. Involvement of c-Jun NH2-terminal kinase 1 in heat-induced apoptotic cell death of human monoblastic leukemia U937 cells. Int. J. Radiat. Biol., 867-874 (2001). PMID: 11571020

49.Hosoi, Y.*, Miyachi, H., Matsumoto, Y., Enomoto, A., Nakagawa, K., Suzuki, N. and Ono, T. Induction of interleukin-1beta and interleukin-6 mRNA by low doses of ionizing radiation in macrophages. Int. J. Cancer, 96, 270-276 (2001). PMID: 11582579

【2000年】

50.Matsumoto, Y.*, Suzuki, N., Namba, N., Umeda, N., Ma, X.-J., Morita, A., Tomita, M., Enomoto, A., Serizawa, S., Hirano, K., Sakai, K., Yasuda, H., and Hosoi, Y. Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation. FEBS Lett. 478, 67-71 (2000). PMID: 10922471

51.Tomita, M., Suzuki, N.*, Matsumoto, Y., Hirano, K., Umeda, N., and Sakai, K. Sensitization by wortmannin of heat- or X-ray induced cell death in cultured chinese hamster V79 cells. J. Radiat. Res. 41, 93-102 (2000). PMID: 11037577

52.Enomoto, A., Suzuki, N.*, Hirano, K., Matsumoto, Y., Morita, A., Sakai, K., and Koyama, H. Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. Cancer Lett. 155, 137-144 (2000). PMID: 10822128

53.Morita, A., Suzuki, N.*, Matsumoto, Y., Hirano, K., Enomoto, A., Zhu, J., and Sakai, K. p41 as a possible marker for cell death is generated by caspase cleavage of p42/SET in irradiated MOLT-4 cells. Biochem. Biophys. Res. Commun., 278, 627-632 (2000). PMID: 11095960

【1999年】

54.Matsumoto, Y., Umeda, N., Suzuki, N.*, Sakai, K., and Hirano, K. A gel-electrophoretic analysis for improved sensitivity and specificity of DNA-dependent protein kinase activity. J. Radiat. Res. 40, 183-196 (1999). PMID: 10494149

【1998年】

55.Hosoi, Y.*, Miyachi, H., Matsumoto, Y., Ikehata, H., Komura, J., Ishii, K., Zhao, H.-J., Yoshida, M., Takai, Y., Yamada, S., Suzuki, N., and Ono, T. A PI-3 kinase inhibitor, wortmannin, induces radioresistant DNA synthesis, and sensitizes cells to bleomycin and ionizing radiation. Int. J. Cancer 78, 642-647 (1998). PMID: 9808536

【1997年】

56.Matsumoto, Y., Suzuki, N.*, Sakai, K., Morimatsu, A., Hirano, K., and Murofushi H. A possible mechanism for hyperthermic radiosensitization mediated through hyperthermic lability of Ku subunits in DNA-dependent protein kinase. Biochem. Biophys. Res. Commun. 234, 568-572 (1997). PMID: 9175753

【1996年】

57.Morimatsu, A., Suzuki, N.*, Hirano, K., Matsumoto, Y., and Sakai, K. Identification and characterization of a protein found after X-irradiation in human T cell leukemia. J. Radiat. Res. 37, 1-11 (1996). PMID: 8699391

【国際会議プロシーディングス】

1.Wanotayan R, Sharma MK, Matsumoto Y. Function of XRCC4 C-terminal Region in DNA Double-Strand Break Repair. The 2014 American Nuclear Society, Winter Meeting, California, USA. Transactions of the American Nuclear Society, Vol. 111, 1145-1148.

【英文総説等(査読有)】

1. Matsumoto, Y.*, Imamichi, S., Fukuchi, M., Liu, S., Wanotayan, R., Kuniyoshi, S., Yoshida, K., Mae, Y., Sharma, M.K. Radiosensitization strategy through modification of DNA double-strand break repair. In “DNA Repair-New Research Directions”, Edit. Chen, C. ISBN 980-953-307-746-3, InTech pp.639-661 (2013)

2.Kamdar, R.P., Matsumoto, Y*. DNA double-strand break repair through non-homologous end-joining: Recruitment and assembly of the players. “DNA Repair”, Edit. Kruman, I. ISBN: 978-953-307-697-3, InTech, pp. 477-502 (2011)

3.Sakata, K.*, Someya, M., Matsumoto, Y., and Hareyama, M. Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity. Radiat. Med. 25, 433-438 (2007). PMID: 18026900

【英文総説等(査読無)】

1.Kumar, A.*, Matsumoto, Y.  Radiation protection by herbs and plants.  In “Emerging Trends in Zoology” Edit. Srivastva, U.C. and Kumar, S. Narendra Publishing House (2011).

【和文総説・解説等】

1.松本義久　「二つのDNA二重鎖切断修復機構の賢い選択」　医学物理　34(2), 1-8 (2014). (Matsumoto, Y. Smart Choice between Two DNA Double-strand Break Repair Mechanisms. Japanese Journal of Medical Physics, 34, 1-8 (2014)

2.松本義久　「放射線の人体影響の生物学的基礎」　日本職業・災害医学会会誌　61, 180-185 (2013). (Matsumoto, Y. Biological Basis of Radiation Effects on Human Health. Japanese Journal of Occupational Medicine and Traumatology, 61, 180-185, 2013)

3.松本義久　「放射線生物研究者から見た放射線のリスク」　全漬研漬物技術　25, 44-64 (2012).

4.松本義久　「放射線生物研究者から見た放射線のリスク　Risk of Radiation from the Aspect of Radiation Biology」　特集・放射性物質を理解する―基礎、測定・検査法、食品や人体への影響―（「フード・フォラム・つくば」より）　食品と開発　47(1), 15-18 (2011).

5.松本義久　「DNA二重鎖切断に対する生体防御機構と医療応用」　表面科学　32(9), 569-574 (2011).(Matsumoto, Y.Biological Defense Mechanism against DNA Double-Strand Break and Its Possible Medical Application.)【査読有】

6.松本義久　「DNA二重鎖切断の修復とシグナル伝達」　細胞 The CELL　43(6), 4-8 (2011).

7.松本義久、Mukesh Kumar Sharma、Radhika Pankaj Kamdar　「非相同末端結合の素過程の解明と臨床応用への展望」　癌の臨床　56, 431-435 (2010).

8.坂田耕一、高木克、染谷正則、田内広、松本義久、晴山雅人、福島正和　「ギメラシルによる放射線増感作用」　癌の臨床　56, 441-443 (2010).

9.松本義久　「DNA切断の「認識」の分子生物学―The End is the Beginning」　電気学会OQD-10-002 (2010).

10.松本義久　「Not at the end of DNA double-strand break repair：新たに発見されたDNA二重鎖切断修復の重要分子XLF/Cernunnos」　放射線生物研究　41, 325-331 (2006).

11.松本義久　「DNA二重鎖切断センサー：DNA依存性プロテインキナーゼ(DNA-PK)機能研究の現状と課題」　放射線生物研究　40, 82-108 (2005).

12.松本義久、梅田典子、冨田雅典、細井義夫、鈴木紀夫　「DNA依存性プロテインキナーゼの性質と放射線感受性-DNA-PKの温熱不安定性と温熱の放射線増感効果について-」　癌の臨床　47, 3-7 (2001).

13.松本義久　「イノシトールヘキサキスリン酸がDNA２重鎖切断の修復に関与する！？」　放射線生物研究　38, 70-73 (2001).

14.松本義久　「DNA依存性プロテインキナーゼ(DNA-PK)とその放射線応答における意義-The end is the beginning of the story.-」　放射線生物研究　31, 1-27 (1996).

15.鈴木紀夫, 酒井一夫, 松本義久. 「癌細胞とApoptosis」　癌と化学療法　20(8), 997-1005 (1993).